Experimental manuscripts:
2020
Le Grand M, Mukha A, Püschel J, Valli E, Kamili A, Vittorio O, Dubrovska A, Kavallaris M.
Interplay between MycN and c-Myc regulates radioresistance and cancer stem cell phenotype in neuroblastoma upon glutamine deprivation.
Theranostics. 2020;10(14):6411-6429.
Arndt C, Loureiro LR, Feldmann A, Jureczek J, Bergmann R, Máthé D, Hegedüs N, Berndt N, Koristka S, Mitwasi N, Fasslrinner F, Lamprecht C, Kegler A, Hoffmann A, Bartsch T, Köseer AS, Egan G, Schmitz M, Hořejší V, Krause M, Dubrovska A, Bachmann M.
UniCAR T cell immunotherapy enables efficient elimination ofradioresistant cancer cells.
Oncoimmunology. 2020;9(1):1743036.
Friedrich M, Wiedemann K, Reiche K, Puppel SH, Pfeifer G, Zipfel I, Binder S, Köhl U, Müller GA, Engeland K, Aigner A, Füssel S, Fröhner M, Peitzsch C, Dubrovska A, Rade M, Christ S, Schreiber S, Hackermüller J, Lehmann J, Toma MI, Muders MH, Sommer U, Baretton GB, Wirth M, Horn F.
The Role of lncRNAs TAPIR-1 and -2 as Diagnostic Markers and Potential Therapeutic Targets in Prostate Cancer.
Cancers (Basel). 2020;12(5):1122.
Terraneo N, Jacob F, Dubrovska A, Grünberg J.
Novel Therapeutic Strategies for Ovarian Cancer Stem Cells.
Front Oncol. 2020;10:319.
Schulz A, Gorodetska I, Behrendt R, Fuessel S, Erdmann K, Foerster S, Datta K, Mayr T, Dubrovska A, Muders MH.
Linking NRP2 With EMT and Chemoradioresistance in Bladder Cancer.
Front Oncol. 2020;9:1461.
Terraneo N, Jacob F, Peitzsch C, Dubrovska A, Krudewig C, Huang YL, Heinzelmann-Schwarz V, Schibli R, Béhé M, Grünberg J.
L1 Cell Adhesion Molecule Confers Radioresistance to Ovarian Cancer and Defines a New Cancer Stem Cell Population.
Cancers (Basel). 2020;12(1):217.
2019
Seifert M, Peitzsch C, Gorodetska I, Börner C, Klink B, Dubrovska A.
Network-based analysis of prostate cancer cell lines reveals novel marker gene candidates associated with radioresistance and patient relapse.
PLoS ComputBiol. 2019;15(11):e1007460.
Cirillo G, Peitzsch C, Vittorio O, Curcio M, Farfalla A, Voli F, Dubrovska A, Iemma F, Kavallaris M, Hampel S.
When polymers meet carbon nanostructures: expanding horizons in cancer therapy.
Future Med Chem. 2019;11(16):2205-2231.
Digomann D, Linge A, Dubrovska A.
SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed.
Autophagy. 2019 Oct;15(10):1850-1851.
Gorodetska I, Kozeretska I, Dubrovska A.
BRCA Genes: The Role in Genome Stability, Cancer Stemness and Therapy Resistance.
J Cancer. 2019;10(9):2109-2127.
Peitzsch C, Nathansen J, Schniewind SI, Schwarz F, Dubrovska A.
Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications.
Cancers (Basel). 2019;11(5):616.
Gorodetska I, Lukiyanchuk V, Peitzsch C, Kozeretska I, Dubrovska A.
BRCA1 and EZH2 cooperate in regulation of prostate cancer stem cell phenotype.
Int J Cancer. 2019;145(11):2974-2985.
Peitzsch C, Kurth I, Ebert N, Dubrovska A, Baumann M.
Cancer stem cells in radiation response: current views and future perspectives in radiation oncology.
Int J Radiat Biol. 2019;95(7):900-911.
Digomann D, Kurth I, Tyutyunnykova A, Chen O, Löck S, Gorodetska I, Peitzsch C, Skvortsova II, Negro G, Aschenbrenner B, Eisenhofer G, Richter S, Heiden S, Porrmann J, Klink B, Schwager C, Dowle AA, Hein L, Kunz-Schughart LA, Abdollahi A, Lohaus F, Krause M, Baumann M, Linge A, Dubrovska A.
The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity.
Clin Cancer Res. 2019;25(10):3152-3163.
2018
Lerra L, Farfalla A, Sanz B, Cirillo G, Vittorio O, Voli F, Le Grand M, Curcio M, Nicoletta FP, Dubrovska A, Hampel S, Iemma F, Goya GF.
Graphene Oxide Functional Nanohybrids with Magnetic Nanoparticles for Improved Vectorization of Doxorubicin to Neuroblastoma Cells. Pharmaceutics. 2018 Dec 22;11(1). pii: E3.
Emiliya A. Domina, Alex Philchenkov, und Anna Dubrovska.
Individual Response to Ionizing Radiation and Personalized Radiotherapy. Critical Reviews in Oncogenesis 23, 1-2 (2018): 69-92.
2017
Vittorio O, Curcio M, Cojoc M, Goya GF, Hampel S, Iemma F, Dubrovska A, Cirillo G. Polyphenols delivery by polymeric materials: challenges in cancer treatment. Drug Deliv. 2017 Nov;24(1):162-180
Coppes RP, Dubrovska A.
Targeting Stem Cells in Radiation Oncology. Clin Oncol (R Coll Radiol). 2017 Jun;29(6):329-334.
Peitzsch C, Tyutyunnykova A, Pantel K, Dubrovska A.
Cancer stem cells: The root of tumor recurrence and metastases. Semin Cancer Biol. 2017 Jun;44:10-24.
Kunz-Schughart LA, Dubrovska A, Peitzsch C, Ewe A, Aigner A, Schellenburg S, Muders MH, Hampel S, Cirillo G, Iemma F, Tietze R, Alexiou C, Stephan H, Zarschler K, Vittorio O, Kavallaris M, Parak WJ, Mädler L, Pokhrel S.
Nanoparticles for radiooncology: Mission, vision, challenges. Biomaterials. 2017 Mar;120:155-184.
Tyutyunnykova A, Telegeev G, Dubrovska A.
The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression. J Cancer. 2017 Feb 25;8(5):716-729.
Krause M, Dubrovska A, Linge A, Baumann M.
Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments. Adv Drug Deliv Rev. 2017 Jan 15;109:63-73.
2016
Linge A, Lohaus F, Löck S, Nowak A, Gudziol V, Valentini C, von Neubeck C, Jütz M, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Buchholz F, Aust DE, Baretton GB, Thames HD, Dubrovska A, Alsner J, Overgaard J, Krause M, Baumann M; DKTK-ROG.
HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). Radiother Oncol. 2016 Dec;121(3):364-373.
Kumar S, Chaudhary AK, Kumar R, O'Malley J, Dubrovska A, Wang X, Yadav N, Goodrich DW, Chandra D.
Combination therapy induces unfolded protein response and cytoskeletal rearrangement leading to mitochondrial apoptosis in prostate cancer. Mol Oncol. 2016 Aug;10(7):949-65.
Linge A, Löck S, Gudziol V, Nowak A, Lohaus F, von Neubeck C, Jütz M, Abdollahi A, Debus J, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Avlar M, Grosu AL, Bayer C, Belka C, Pigorsch S, Combs SE, Welz S, Zips D, Buchholz F, Aust DE, Baretton GB, Thames HD, Dubrovska A, Alsner J, Overgaard J, Baumann M, Krause M; DKTK-ROG.
Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG. Clin Cancer Res. 2016 Jun 1;22(11):2639-49.
Vittorio O, Cojoc M, Curcio M, Spizzirri UG, Hampel S, Nicoletta FP, Iemma F, Dubrovska A, Kavallaris M, Cirillo G.
Polyphenol Conjugates by Immobilized Laccase: The Green Synthesis of Dextran-Catechin. Macromol. Chem. Phys. 2016 May 6;217(13):1488–1492.
Peitzsch C*, Cojoc M*, Hein L, Kurth I, Mäbert K, Trautmann F, Klink B, Schröck E, Wirth MP, Krause M, Stakhovsky EA, Telegeev GD, Novotny V, Toma M, Muders M, Baretton GB, Frame FM, Maitland NJ, Baumann M, Dubrovska A.
An Epigenetic Reprogramming Strategy to Resensitize Radioresistant Prostate Cancer Cells. Cancer Res. 2016 May 1;76(9):2637-51.
Zscheppang K, Kurth I, Wachtel N, Dubrovska A, Kunz-Schughart LA, Cordes N.
Efficacy of Beta1 Integrin and EGFR Targeting in Sphere-Forming Human Head and Neck Cancer Cells. J Cancer. 2016 Apr 2;7(6):736-45.
2015
Castro Nava A, Cojoc M, Peitzsch C, Cirillo G, Kurth I, Fuessel S, Erdmann K, Kunhardt D, Vittorio O, Hampel S, Dubrovska A.
Development of novel radiochemotherapy approaches targeting prostate tumor progenitor cells using nanohybrids. Int J Cancer. 2015 Nov 15;137(10):2492-503.
Kurth I, Hein L, Mäbert K, Peitzsch C, Koi L, Cojoc M, Kunz-Schughart L, Baumann M, Dubrovska A.
Cancer Stem Cell Related Markers of Radioresistance in Head and Neck Squamous Cell Carcinoma. Oncotaget. 2015 Oct 27;6(33):34494-509.
Cojoc M*, Peitzsch C*, Kurth I, Trautmann F, Kunz-Schughart LA, Telegeev GD, Stakhovsky EA, Walker JR, Simin K, Lyle S, Fuessel S, Erdmann K, Wirth MP, Krause M, Baumann M, Dubrovska A.
Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells. Cancer Res. 2015 Apr 1;75(7):1482-94.
2014
Masjkur J, Arps-Forker C, Poser SW, Nikolakopoulou P, Toutouna L, Chenna R, Chavakis T, Chatzigeorgiou A, Chen LS, Dubrovska A, Choudhary P, Uphues I, Mark M, Bornstein SR, Androutsellis-Theotokis A.
Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release. J Biol Chem. 2014 Dec 19;289(51):35503-16.
Economopoulou M, Masjkur J, Raiskup F, Ebermann D, Saha S, Karl MO, Funk R, Jaszai J, Chavakis T, Ehrhart-Bornstein M, Pillunat LE, Kunz-Schughart L, Kurth I, Dubrovska A, Androutsellis-Theotokis A.
Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. Int J Radiat Biol. 2014 Aug;90(8):700-9.
2013
Kim CH, Axup JY, Lawson BR, Yun H, Tardif V, Choi SH, Zhou Q, Dubrovska A, Biroc SL, Marsden R, Pinstaff J, Smider VV, Schultz PG.
Bispecific small molecule-antibody conjugate targeting prostate cancer. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17796-801.
Zakharchenko O, Cojoc M, Dubrovska A, Souchelnytskyi S.
A role of TGFß1 dependent 14-3-3σ phosphorylation at Ser69 and Ser74 in the regulation of gene transcription, stemness and radioresistance. PLoS One. 2013 May 31;8(5):e65163.
Kim S, Dubrovska A, Salamone RJ, Walker JR, Grandinetti KB, Bonamy GM, Orth AP, Elliott J, Porta DG, Garcia-Echeverria C, Reddy VA.
FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. PLoS One. 2013;8(1):e51671.
Review manuscripts:
2019
Schulz A, Meyer F, Dubrovska A, Borgmann K.
Cancer Stem Cells and Radioresistance: DNA Repair and Beyond. Cancers 2019 11(6). pii: E862.
2018
Skvortsov S, Skvortsova II, Tang DG, Dubrovska A.
Concise Review: Prostate Cancer Stem Cells: Current Understanding. Stem Cells. 2018 Oct;36(10):1457-1474.
2016
Krause M, Dubrovska A, Linge A, Baumann M.
Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments. Adv Drug Deliv Rev. 2016 Feb 12. pii: S0169-409X(16)30052-7.
2015
Kuhlmann JD, Hein L, Kurth I, Wimberger P, Dubrovska A.
Targeting cancer stem cells: promises and challenges. ACAMC (Anti-Cancer Agents in Medicinal Chemistry), 2015, PMID:26179271
Cojoc M, Mäbert K, Muders MH, Dubrovska A.
A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms. Semin Cancer Biol. 2015 Apr;31:16-27.
2014
Dubrovska A.
Report on the International Workshop 'Cancer stem cells: the mechanisms of radioresistance and biomarker discovery. Int J Radiat Biol. 2014 Aug;90(8):607-14.
Peitzsch C, Perrin R, Hill RP, Dubrovska A, Kurth I.
Hypoxia as a biomarker for radioresistant cancer stem cells. Int J Radiat Biol. 2014 Aug;90(8):636-52.
Trautmann F, Cojoc M, Kurth I, Melin N, Bouchez LC, Dubrovska A, Peitzsch C.
CXCR4 as biomarker for radioresistant cancer stem cells. Int J Radiat Biol. 2014 Aug;90(8):687-99.
Mäbert K, Cojoc M, Peitzsch C, Kurth I, Souchelnytskyi S, Dubrovska A.
Cancer biomarker discovery: current status and future perspectives. Int J Radiat Biol. 2014 Aug;90(8):659-77.
2013
Cojoc M, Peitzsch C, Trautmann F, Polishchuk L, Telegeev GD, Dubrovska A.
Emerging targets in cancer management: role of the CXCL12/CXCR4 axis. Onco Targets Ther. 2013 Sep 30;6:1347-61.
Bütof R, Dubrovska A, Baumann M.
Clinical perspectives of cancer stem cell research in radiation oncology. Radiother Oncol. 2013 Sep;108(3):388-96.
Peitzsch C, Kurth I, Kunz-Schughart L, Baumann M, Dubrovska A.
Discovery of the cancer stem cell related determinants of radioresistance. Radiother Oncol. 2013 Sep;108(3):378-87.
2012
Dubrovska A, Abdollahi A, Tinhofer I.
Cancer stem cells and high-throughput screening methods. Strahlenther Onkol. 2012 Nov;188 Suppl 3:316-9.
Book chapters
2019
Dubrovska A, Krause M, Baumann M.
Biological effect of radiotherapy on cancer cells. Oxford Textbook of Cancer Biology. Oxford Textbook of Cancer Biology. DOI: 10.1093/med/9780198779452.003.0030. ISBN: 9780198779452. Publisher: Oxford University Press
2016
Linge A, Dubrovska A, Baumann M, Krause M.
The Role of Cancer Stem Cells in Tumour Radioresponse. Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment. Edited by Anscher MS and Valerie K. Springer, 2016, ISBN-13: 978-3-319-45592-1
2015
Peitzsch C, Cojoc M, Kurth I, Dubrovska A.
Role of the CXCR4/ CXCL12 in cancer and cancer stem cells. Cancer Stem Cells: Emerging Concepts and Future, First Edition. Edited by S. Babashah. Springer, 2015, ISBN-13: 978-3319210292
2014
Kurth I*, Peitzsch C*, Baumann M, Dubrovska A. The role of cancer stem cells in tumor radioresistance. Cancer Stem Cells, First Edition. Edited by V. K. Rajasekhar. John Wiley & Sons Inc, 2014, ISBN-13: 978-1-118-35616-6
